Nesher Technologies, Inc.
Nanobiotech for smarter diagnostics and cutting-edge biomedical research

Relevant Scientific Papers

  1. Kim, T., Reitmair, A. Non-coding RNAs: Functional aspects and diagnostic utility in oncology. International Journal of Molecular Sciences 14(3): 4934-68 (2013).
  2. Chakraborty, A., Wang, D., Ebright, Y.W., Korlann, Y., Kortkhonjia, E., Kim, T., Chowdhury, S., Wigneshweraraj, S., Irschik, H., Jansen, R., Nixon, B.T., Knight, J., Weiss, S. & Ebright, R.H. Opening and closing of the bacterial RNA polymerase clamp. Science 337, 591-5 (2012).
  3. Yim, S.W., Kim, T., Laurence, T.A., Partono, S., Kim, D., Kim, Y., Weiss, S. & Reitmair, A. Four-color alternating laser excitation single-molecule fluorescence spectroscopy for next-generation biodetection assays. Clinical Chemistry 58, 707-16 (2012).
  4. Ingargiola, A., Colyer, R.A., Kim, D., Panzeri, F., Lin, R., Gulinatti, A., Rech, I., Ghioni, M., Weiss, S. & Michalet, X. Parallel multispot smFRET analysis using an 8-pixel SPAD array. Proceedings of SPIE 8228(2012).
  5. Kim, S., Streets, A.M., Lin, R.R., Quake, S.R., Weiss, S. & Majumdar, D.S. High-throughput single-molecule optofluidic analysis. Nat Methods 8, 242-5 (2011).
  6. Colyer, R.A., Scalia, G., Rech, I., Gulinatti, A., Ghioni, M., Cova, S., Weiss, S. & Michalet, X. High-throughput FCS using an LCOS spatial light modulator and an 8 x 1 SPAD array. Biomed Opt Express 1, 1408-1431 (2010).
  7. Michalet, X., Colyer, R.A., Scalia, G., Kim, T., Levi, M., Aharoni, D., Cheng, A., Guerrieri, F., Arisaka, A., Millaud, J., Rech, I., Resnati, D., Marangoni, S., Gulinatti, A., Ghioni, M., Tisa, S., Zappa, F., Cova, S. & Weiss, S. High-throughput single-molecule fluorescence spectroscopy using parallel detection. Proceedings of SPIE 7608, 76082D-1 (2010).
  8. Colyer, R.A., Scalia, G., Kim, T., Rech, I., Resnatic, D., Marangonic, S., Ghionic, M., Cova, S., Weiss, S. & Michalet, X. High-throughput multispot single-molecule spectroscopy. Proceedings of SPIE 7571(2010).
  9. Lee, N.K., Kapanidis, A.N., Koh, H.R., Korlann, Y., Ho, S.O., Kim, Y., Gassman, N., Kim, S.K. & Weiss, S. Three-color alternating-laser excitation of single molecules: monitoring multiple interactions and distances. Biophys J 92, 303-12 (2007).
  10. Michalet, X., Weiss, S. & Jager, M. Single-molecule fluorescence studies of protein folding and conformational dynamics. Chemical reviews 106, 1785-813 (2006).
  11. Kapanidis, A.N., Margeat, E., Ho, S.O., Kortkhonjia, E., Weiss, S. & Ebright, R.H. Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism. Science 314, 1144-7 (2006).
  12. Margeat, E., Kapanidis, A.N., Tinnefeld, P., Wang, Y., Mukhopadhyay, J., Ebright, R.H. & Weiss, S. Direct observation of abortive initiation and promoter escape within single immobilized transcription complexes. Biophys J 90, 1419-1431 (2006).
  13. Jager, M., Nir, E. & Weiss, S. Site-specific labeling of proteins for single-molecule FRET by combining chemical and enzymatic modification. Protein Sci 15, 640-6 (2006).
  14. Nir, E., Michalet, X., Hamadani, K.M., Laurence, T.A., Neuhauser, D., Kovchegov, Y. & Weiss, S. Shot-noise limited single-molecule FRET histograms: comparison between theory and experiments. Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces & Biophysical 110, 22103-24 (2006).
  15. Kapanidis, A.N., Laurence, T.A., Lee, N.K., Margeat, E., Kong, X. & Weiss, S. Alternating-Laser Excitation of Single Molecules. Acc Chem Res 38, 523-533 (2005).
  16. Kapanidis, A.N., Margeat, E., Laurence, T.A., Doose, S., Ho, S.O., Mukhopadhyay, J., Kortkhonjia, E., Mekler, V., Ebright, R.H. & Weiss, S. Retention of Transcription Initiation Factor sigma(70) in Transcription Elongation: Single-Molecule Analysis. Mol Cell 20, 347-56 (2005).
  17. Laurence, T.A., Kong, X., Jager, M. & Weiss, S. Probing structural heterogeneities and fluctuations of nucleic acids and denatured proteins. Proc Natl Acad Sci U S A 102, 17348-53 (2005).
  18. Lee, N.K., Kapanidis, A.N., Wang, Y., Michalet, X., Mukhopadhyay, J., Ebright, R.H. & Weiss, S. Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation. Biophys J 88, 2939-53 (2005).
  19. Jager, M., Michalet, X. & Weiss, S. Protein-protein interactions as a tool for site-specific labeling of proteins. Protein Sci 14, 2059-68 (2005).
  20. Kapanidis, A.N., Lee, N.K., Laurence, T.A., Doose, S., Margeat, E. & Weiss, S. Fluorescence-aided molecule sorting: Analysis of structure and interactions by alternating-laser excitation of single molecules. Proceedings of the National Academy of Sciences of the United States of America 101, 8936-41 (2004).