Nesher Technologies, Inc.
Nanobiotech for smarter diagnostics and cutting-edge biomedical research

Products : Instrumentation

ALEX analyzer for basic research and drug discovery applications

A life science application version of the ALEX analyzer for non-diagnostic uses, not requiring clinical validation and regulatory approval, is available upon custom-order with a lead time of 6-9 months.

NTI is currently finalizing development of a user-friendly confocal 2-color ALEX table-top prototype instrument with enhanced software integration for real time data acquisition customizable for different applications to be available to the research community. NTI is offering a limited number of 2c-ALEX prototype single molecule analyzers at a substantially reduced price in return for participation in our beta-testing program.

Technical details and specifications can be found here. To inquire about options, pricing, and to place an order, please contact us.

Multiplexed FRET-based ALEX single molecule spectroscopy 4 u: Visualize molecular dynamics and gear up for true breakthrough discovery!

ALEX analyzer for in vitro diagnostics (IVD) applications

The laser-based ALEX analyzer for diagnostics applications will be a “sample-in, answer-out” instrumentation, integrating fully automated microfluidics-based sample handling features ("single molecule optofluidics"1) and minimizing sample and reagent requirements. The automated microfluidics-based ALEX analyzer will integrate seamlessly into the clinical laboratory work flow, requiring only minimal technician hands-on time.

To dramatically increase throughput, NTI will implement a new multispot excitation and detection system made possible by combination of several new powerful technologies2-5, currently being developed in Professor Weiss’ Single Molecule Biophysics Lab, which will allow to stepwise increase throughput by factors of 64, 256, and 1024.

1. S. Kim et al., Nat Methods 8, 242 (2011)
2. A. Ingargiola et al.,Proceedings of SPIE, 8228 (2012)
3. X. Michalet et al.,Proceedings of SPIE, 76082D-1 (2010)
4. R.A. Colyer et al.,Biomed Opt Express 1, 1408 (2010)
5. R.A. Colyer et al., Proceedings of SPIE, 7571 (2010)